The best hospital in Wuxi to treat amyloidosis [Wuxi Zhongyan Dermatology Institute, consultation hotline, consultation]
Primary cutaneous amyloidosis is caused by the deposition of amyloid protein substances in the skin. Amyloid is a complex of globulin and mucopolysaccharides, named for its starch-like chemical reactions such as iodine reactions, but actually has nothing to do with starch. Some people have suggested that this disease is inherited in an autosomal dominant manner, and in some cases there are abnormalities in blood lipids and proteins, so it is believed to be related to metabolic disorders. Some patients have a family history. It affects more men than women, is more common in young adults, and can last for years or decades.
In different biochemical types of amyloidosis, the etiological mechanisms may be different. For example, secondary amyloidosis is a metabolic disorder of protein precursors, while hereditary amyloidosis will produce different proteins. In primary amyloidosis, monoclonal populations of bone marrow cells produce amyloid-forming fragments or entire long chains. Under light microscopy, amyloid is homogeneous, high-affinity, and in fixed tissue. There are substances that neutralize Congo red dye and are compatible with it.
What are the clinical manifestations of cutaneous amyloidosis?
In primary amyloidosis, the heart, lungs, skin, tongue, thyroid and intestines are often affected, and localized masses can be found in the respiratory tract and other parts of the solid organs (liver, spleen, kidneys) and heart. The vascular system, especially the heart, is often affected.
Secondary amyloidosis shows involvement of the spleen, liver, kidneys, adrenal glands, and lymph nodes. Although clinical signs of cardiac involvement are rare, the cardiovascular system is often extensively involved, the kidneys are often enlarged, and the liver and spleen are often enlarged. The texture becomes hard and rubbery. As the normal splenic corpuscles are replaced by white amyloidosis, the spleen becomes enlarged and appears translucent and waxy, which is called sago spleen.
Hereditary amyloidosis is characterized by peripheral sensory and motor (often autonomic) and cardiovascular and renal amyloidosis. Carpal tunnel syndrome and vitreous abnormalities are often present.
Warm reminder: Wuxi Zhongyan Institute of Dermatology has opened an expert online consultation service. Authoritative experts will answer your related disease questions online and give you more professional medical guidance and treatment plans according to the severity of your condition, saving you unnecessary time. Cost, grasp the best opportunity for treatment, and must not blindly use medication to avoid worsening of the condition and causing adverse consequences.
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